Arthrosamid Knee Injections in London | £2299

About Arthrosamid Knee Injections in London

What is Arthrosamid?

Arthrosamid® is a long-acting injectable treatment used to help manage pain and stiffness caused by knee osteoarthritis. It is designed for people who are seeking a non-surgical option when symptoms persist despite exercise, physiotherapy, or other injections.

Arthrosamid is made from a biocompatible polyacrylamide hydrogel. Once injected into the knee joint, the gel integrates with the synovial tissue (the lining of the joint), helping to improve cushioning and shock absorption within the knee. Unlike steroid or hyaluronic acid injections, Arthrosamid is not broken down quickly by the body, which is why it can provide longer-lasting symptom relief.

The Science Behind Arthrosamid

Arthrosamid® is composed of 97.5% water and 2.5% cross-linked polyacrylamide hydrogel, a material designed to be stable, non-degradable, and biocompatible within the knee joint environment.

Once injected, Arthrosamid does not behave like a temporary lubricant. Instead, the hydrogel integrates with the synovial tissue lining the knee joint. Over time, it forms a durable, cushioning matrix within the joint, helping to absorb mechanical forces and reduce friction during movement.

Because Arthrosamid is not rapidly broken down or absorbed by the body, its effect is fundamentally different from steroid injections, which act by reducing inflammation temporarily, or hyaluronic acid injections, which are gradually degraded. This structural stability is what allows Arthrosamid to provide longer-lasting symptom relief for some patients.

From a biomechanical perspective, the hydrogel helps to:

• Improve shock absorption within the knee

• Reduce stress on irritated joint surfaces

• Support smoother joint movement during everyday activities

Arthrosamid does not reverse osteoarthritis or regenerate cartilage. Instead, it is designed to modify the joint environment, helping to reduce pain and stiffness and improve comfort for people with mild to moderate knee osteoarthritis.

Clinical studies have demonstrated sustained improvements in pain and function in appropriately selected patients, though individual results may vary but early trials have indicated injections may be more successful in more active individuals with moderate osteoarthritis.

Research Publications Concerning Arthrosamid Injections

Effectiveness and safety of polyacrylamide hydrogel injection for knee osteoarthritis: results from a 12-month follow up of an open-label study | Journal of Orthopaedic Surgery and Research 

https://doi.org/10.1186/s13018-024-04756-2

This open-label clinical study assessed the effectiveness and safety of a single intra-articular injection of polyacrylamide hydrogel in patients with knee osteoarthritis over 12 months. The results showed sustained and clinically meaningful improvements in pain, stiffness, and physical function throughout the follow-up period, with a majority of patients meeting established responder criteria. The treatment was generally well tolerated, with no major safety concerns identified, supporting polyacrylamide hydrogel as a potentially durable symptomatic treatment option for knee osteoarthritis.

Polyacrylamide gel versus hyaluronic acid for the treatment of knee osteoarthritis: a randomised controlled study 

https://doi.org/10.1097/MD.0000000000044655

In this retrospective cohort analysis published in Medicine, researchers examined medical records of people with knee osteoarthritis who received a single intra-articular injection of polyacrylamide hydrogel, hyaluronic acid, or corticosteroids. All three treatments resulted in improvements in pain and function in the short term, but polyacrylamide hydrogel tended to provide more sustained relief than corticosteroids and showed similar effectiveness to hyaluronic acid at follow-up. While differences between groups diminished over longer follow-up, patient-reported outcomes such as meaningful improvement and acceptable symptom state were generally more favorable with polyacrylamide hydrogel, suggesting it may offer a viable alternative to traditional viscosupplementation and steroid injections for symptom management in knee osteoarthritis.

A Systematic Review of the Novel Compound Arthrosamid Polyacrylamide (PAAG) Hydrogel for Treatment of Knee Osteoarthritis | Medical Research Archives 

https://doi.org/10.18103/mra.v10i8.2950

This systematic review looked at all available clinical evidence on polyacrylamide (PAAG) hydrogel injections — including Arthrosamid — for knee osteoarthritis by searching major medical databases up to April 2022. Across multiple studies involving a total of 463 patients, the review found that intra-articular PAAG hydrogel injections were generally safe and associated with statistically significant improvements in pain and function at 12 months and longer follow-up in several cohorts. In a randomized trial included in the review, PAAG hydrogel showed numerically better outcomes than hyaluronic acid, and some longer-term data suggested symptom relief could persist for up to two years. Adverse events were generally mild, and no serious long-lasting safety issues were reported, supporting the conclusion that PAAG hydrogel is a promising treatment option for knee osteoarthritis with sustained benefit and a favorable safety profile at least up to two years post-injection.

Prophylactic Antibiotics prior to Arthrosamid Knee Injections

Why a Single Dose of Antibiotics Is Used Prior to Arthrosamid Injections?

As Arthrosamid is a long-acting injectable treatment, a single dose of antibiotics will be prescribed as a precautionary measure to help reduce the risk of infection associated with the injection. Although infection is uncommon, this forms part of a strict safety-focused treatment protocol used when delivering a hydrogel that remains within the joint.

The antibiotic dose is given in addition to full sterile technique and ultrasound-guided injection, supporting patient safety and reassurance.

https://arthrosamid.ams3.cdn.digitaloceanspaces.com/new-uploads/downloads/Statement-on-the-use-of-prophylactic-antibotics-with-Arthrosamid-injections.pdf

Accurate Ultrasound-Guided Arthrosamid Injections in London

Chris Pruvey has extensive experience in ultrasound-guided musculoskeletal injections, developed through both NHS and private practice, and applies a structured, image-guided approach when delivering Arthrosamid knee injections across a network of clinics in London.

All Arthrosamid injections are performed using real-time ultrasound guidance, allowing continuous visualisation of the knee joint, surrounding structures, and needle pathway throughout the procedure. This enables precise intra-articular placement, with accuracy confirmed visually during the injection rather than assumed using anatomical landmarks alone.

A strict, standardised protocol is followed for every procedure. Treatment is delivered in two stages:

First, a local anaesthetic injection is administered under ultrasound guidance to improve comfort and clearly define the injection pathway. This is followed by a second injection delivering the full Arthrosamid dose (six vials) into the knee joint.

The injection is consistently performed using a supralateral recess approach in keeping with Contura Arthrosamid's evidence based protocols. This allows minimal pain and access to the joint space (within the joint capsule) and uninterrupted ultrasound visualisation. This technique provides clear confirmation that the Arthrosamid hydrogel has been accurately delivered into the joint under direct imaging guidance.

Each procedure is documented with ultrasound images, and where appropriate, video recordings are captured during the injection. These records are available for each patient, offering reassurance, transparency, and visual confirmation of accurate joint placement.

Post Arthrosamid Injection Guidance

• Rest and avoid strenuous activity for the first 24–72 hours after the injection.

• Gradual return to normal daily activities over the first 2 weeks.

• Contact Chris for a follow up here 2 weeks following your Arthrosamid injection.